Category: Featured
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New stem cell partnership for CellBank
CellBank Australia has partnered with the European Bank for induced pluripotent Stem Cells (EBiSC) to enable our Oceania-based customers to access over 950 induced pluripotent stem cell (iPSC) lines representing over 45 different diseases. This includes gene-edited iPSC cells and pre-differentiated iPSC-Neurons. For over ten years, EBiSC has worked to enhance research outcomes by providing…
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Pilot Study Promotion – Single Cell Analytics
We are excited to announce an exclusive Pilot Study Promotion at CMRI’s Single Cell Analytics Facility! From 12th August to 30th September, you can take advantage of this unique opportunity with no minimum sample requirement and receive preliminary bioinformatic analysis. Why Participate? Discover how Single Cell Transcriptomics can elevate your research by running a single…
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Disease modelling using Organoids and Single Cell Transcriptomics
Organoids are mini-organs grown in the dish using 3D differentiation systems and have been shown to be an important tool in precision and regenerative medicine, as well as drug discovery research. When combined with the power of single cell transcriptomics, which enables transcriptomic information to be measured on thousands of single cells in a complex…
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Lipid Nanoparticles are now offered by CMRI’s Peptide Synthesis Facility
A recent publication co-authored by CMRI’s Peptide Synthesis Facility’s Dr Md Musfizur Hassan, examined how nanoparticles can be used to predict the in vivo transport and drug delivery outcomes of various nanomedicine formulations across the blood brain barrier1. Nanoparticles are small particles (1-100nm) that are used for different clinical applications as a dosage form of…
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Working Towards Better Drug Delivery Systems for Chemotherapeutics
Working Towards Better Drug Delivery Systems for Chemotherapeutics A recent investigation by CMRI’s Peptide Facility Lead, Dr. Md Musfizur Hassan (1st author) and his collaborators at University of New South Wales and University of South Australia, explored the use of liposome-micelle-hybrid (LMH) carriers to enhance the delivery of the clinically relevant chemotherapeutics Paclitaxel (PTX) and…
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Stem Cell and Organoid Facility benefits from Biorobotics upgrades
Stem Cell and Organoid Facility benefits from Biorobotics upgrades Biorobotics equipment purchases have been proceeding throughout this year ahead of a planned redevelopment for early next year that will enable the Stem Cell Medicine Group to develop Goods Manufacturing Process (GMP) protocols. This started with the purchase of the Hamilton STAR liquid handling platform in…
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FDA approves organoids for pre-clinical studies
The US Federal Drug Administration (FDA) is now encouraging the use of cellular assays such as organoids for pre-clinical studies. CMRI’s Stem Cell & Organoid Facility welcomed the announcement by the FDA in December 2022 which stated that it is no longer a requirement of the FDA to have all drugs tested in rodent and…
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Proteomics for progressive muscular dystrophy
Leading scientists from Biomedical Proteomics and Bioinformatics at CMRI contributed to a recent article that advanced understanding of dysferlinopathy, a progressive muscular dystrophy disease. The study was led by Dr Frances Lemckert at the Kids Neuroscience Centre, The Children’s Hospital at Westmead. Dr Lemckert’s team use CRISPR/Cas9 gene editing to knock out murine Dysf exon…
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Imaging that is transforming how we think about cancer
Thanks to the equipment available in CMRI’s Imaging Facility, Dr Noa Lamm-Shalem was able to make an unexpected discovery about cancer cells, published in Nature Cell Biology. Dr Lamm-Shalem found that when cancer cells encounter problems replicating their DNA, actin cables form inside the nucleus. This allows the nucleus to change shape and increases the ability…
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Single Cell Analytics Facility enables prize winning results
PhD student, Lara Graves, won the best oral presentation prize in the Adrenal and HPA axis category for her preliminary work at the 2023 International Meeting of Paediatric Endocrinology in Buenos Aires, Argentina. She impressed the international audience with her data on the murine single cell transcriptome in 21-hydroxylase deficiency. 21-hydroxylase deficiency is the most…