Category: Science Publications
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Lipid Nanoparticles are now offered by CMRI’s Peptide Synthesis Facility
A recent publication co-authored by CMRI’s Peptide Synthesis Facility’s Dr Md Musfizur Hassan, examined how nanoparticles can be used to predict the in vivo transport and drug delivery outcomes of various nanomedicine formulations across the blood brain barrier1. Nanoparticles are small particles (1-100nm) that are used for different clinical applications as a dosage form of…
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Proteomics and Nature Communications Publications
Dr Mark Graham, Research Facility Lead for the Biomedical Proteomics Facility, was an author on a publication looking at the molecular changes that occur in ageing brains that was published in Proteomics. Read more: https://pubmed.ncbi.nlm.nih.gov/38115172/ He also contributed to a Nature Communications paper showing how a large-scale activity-dependent phosphoproteome analysis of hippocampal neurons in vitro and helped identify involvement of Tau in…
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Working Towards Better Drug Delivery Systems for Chemotherapeutics
Working Towards Better Drug Delivery Systems for Chemotherapeutics A recent investigation by CMRI’s Peptide Facility Lead, Dr. Md Musfizur Hassan (1st author) and his collaborators at University of New South Wales and University of South Australia, explored the use of liposome-micelle-hybrid (LMH) carriers to enhance the delivery of the clinically relevant chemotherapeutics Paclitaxel (PTX) and…
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Proteomics for progressive muscular dystrophy
Leading scientists from Biomedical Proteomics and Bioinformatics at CMRI contributed to a recent article that advanced understanding of dysferlinopathy, a progressive muscular dystrophy disease. The study was led by Dr Frances Lemckert at the Kids Neuroscience Centre, The Children’s Hospital at Westmead. Dr Lemckert’s team use CRISPR/Cas9 gene editing to knock out murine Dysf exon…
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Imaging that is transforming how we think about cancer
Thanks to the equipment available in CMRI’s Imaging Facility, Dr Noa Lamm-Shalem was able to make an unexpected discovery about cancer cells, published in Nature Cell Biology. Dr Lamm-Shalem found that when cancer cells encounter problems replicating their DNA, actin cables form inside the nucleus. This allows the nucleus to change shape and increases the ability…