Category: News
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FDA approves organoids for pre-clinical studies
The US Federal Drug Administration (FDA) is now encouraging the use of cellular assays such as organoids for pre-clinical studies. CMRI’s Stem Cell & Organoid Facility welcomed the announcement by the FDA in December 2022 which stated that it is no longer a requirement of the FDA to have all drugs tested in rodent and…
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Proteomics for progressive muscular dystrophy
Leading scientists from Biomedical Proteomics and Bioinformatics at CMRI contributed to a recent article that advanced understanding of dysferlinopathy, a progressive muscular dystrophy disease. The study was led by Dr Frances Lemckert at the Kids Neuroscience Centre, The Children’s Hospital at Westmead. Dr Lemckert’s team use CRISPR/Cas9 gene editing to knock out murine Dysf exon
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Imaging that is transforming how we think about cancer
Thanks to the equipment available in CMRI’s Imaging Facility, Dr Noa Lamm-Shalem was able to make an unexpected discovery about cancer cells, published in Nature Cell Biology. Dr Lamm-Shalem found that when cancer cells encounter problems replicating their DNA, actin cables form inside the nucleus. This allows the nucleus to change shape and increases the ability
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Single Cell Analytics Facility enables prize winning results
PhD student, Lara Graves, won the best oral presentation prize in the Adrenal and HPA axis category for her preliminary work at the 2023 International Meeting of Paediatric Endocrinology in Buenos Aires, Argentina. She impressed the international audience with her data on the murine single cell transcriptome in 21-hydroxylase deficiency. 21-hydroxylase deficiency is the most